Fig. 4

PPI network analysis and screening of the core genes. (A) PPI network of all target genes of down-regulated miRNAs. (B) PPI network of target genes whose Degree value ≥ 10. (C) PPI network of target genes whose Degree value ≥ 20. (D) Cluster analysis by MCODE in Cytoscape Software. The top 30 core genes selected by Degree (E), Clustering Coefficient (F), Maximal Clique Centrality (MCC) (G), Edge Percolated Component (EPC) (H) algorithm in Cytohubba of Cytoscape Software