Fig. 10

Autonomic nerve markers at the right-sided SAN in mice and humans during late cardiogenesis. A–D Mouse sections of the right-sided SAN (white dotted line) at E18.5. Large TUBB3⁺ nerves are observed in the periphery of the SAN (white arrows), co-expressing both ChAT (C) and TH (D). Note the large amount of TH⁺/TUBB3⁻ cells, i.e. ICA cells (B and C). A’–D’ Human sections of the right-sided SAN (white dotted line) at 11WGA. The SAN is highly innervated. Notably, the nerves are located more centrally compared to mice. ICA cells are not present. Scalebars: 100 μm. RCV; right cardinal vein