Table 4 Clinical characteristics for the identified DR candidates
From: Reversal gene expression assessment for drug repurposing, a case study of glioblastoma
Drug Candidates | Cluster ID | BBB | #Clinical Trials | FDA-Approved Indications |
|---|---|---|---|---|
Temozolomide | 8 | 0.9879 | 169 | Glioblastoma multiforme, refractory anaplastic astrocytoma |
Dasatinib | 8, 3 | 0.507 | 5 | Acute lymphoblastic leukemia; chronic myeloid leukemia |
Sirolimus | 8, 3 | 0.9599 | 5 | Lymphangioleiomyomatosis and adults with perivascular epithelioid cell tumors |
Etoposide | 8 | 0.9609 | 5 | Testicular and small cell lung tumors |
Topotecan | 8, 3 | 0.9659 | 3 | Ovarian cancer, small cell lung cancer, or cervical cancer |
Cabozantinib | 8 | Yes* | 3 | Advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer |
Mitomycin | 8 | 0.9659 | 3 | Chemotherapeutic agent for various malignancies |
Dacarbazine | 8 | 0.9382 | 2 | Malignant melanoma and Hodgkin's disease |
Temsirolimus | 8 | 0.9494 | 2 | Renal cell carcinoma |
Bortezomib | 1 | 0.6533 | 2 | Multiple myeloma |
Axitinib | 8 | Yes* | 2 | Advanced renal cell carcinoma |
Gemcitabine | 8 | 0.9693 | 1 | Adjunct therapy for ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer |
Cytarabine | 8 | 0.9465 | 1 | Acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia |
Romidepsin | 8 | Yes* | 1 | Cutaneous T-cell lymphoma |
Simvastatin | 8 | 0.9422 | 1# | Lower lipid levels and reduce the risk of cardiovascular events |
Docetaxel | 8 | Poor* | 1# | Locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, head and neck cancer |
Thalidomide | 8 | 0.9382 | 1 | Newly diagnosed multiple myeloma, erythema nodosum leprosum |
Epirubicin hydrochloride | 8 | 0.9951 | 1# | Axillary node metastases in patients of primary breast cancer |
Tigecycline | 8 | 0.9836 | 0 | Bacterial infections |
Podofilox | 8 | 0.5388 | 0 | External genital warts and perianal warts |
Prochlorperazine | 8 | 0.9781 | 0 | Schizophrenia and anxiety and to relieve severe nausea and vomiting |
Clofarabine | 8 | 0.9827 | 0 | Relapsed or refractory acute lymphoblastic leukemia |
Ciclopirox | 8 | 0.9892 | 0 | Mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients |
Tacrolimus | 8 | 0.9659 | 0 | Prevent organ transplant rejection and to treat moderate to severe atopic dermatitis |