Fig. 3

Impact of CSF1R expression on survival prognosis and immune function. a UMAP plot of single cells from twelve patient-derived primary HNSCC samples, n = 7. b UMAP of CSF1R expression in tumor-specific clusters. c Pearson correlation between CSF1R expression and various cell types in the TCGA-HNSCC. d Spearman correlation analysis between CSF1R expression and TAMs infiltration levels in the TCGA-HNSCC cohort. e Spearman correlation analysis between CSF1R expression and M2 TAMs infiltration levels in the TCGA-HNSCC cohort. f Expression levels of CSF1R in tumor and adjacent non-tumor tissues from the TCGA-HNSCC database. g Patients in the GSE220270 dataset were divided into low and high CSF1R/CD68 groups based on the minimum p-value statistics. Disease-free survival was analyzed using Kaplan–Meier curves and the log-rank test (p = 0.025), n = 109. h GO enrichment analysis of low CSF1R TAMs involved in antigen binding and activation functions in the GSE188737 single-cell dataset