Table 2 Study on the effect of BMSC-exos on promoting angiogenesis
From: Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears
Exosome origin | Equipped with miRNA | Animal models | Biological function | Mechanism/signaling pathway | Cite |
|---|---|---|---|---|---|
Rat BMSC | Â | Mouse model of rotator cuff reconstruction | Promoting angiogenesis and inhibitting inflammation to promote tendon bone healing after rotator cuff reconstruction | Regulating angiogenic signalling pathways | [92] |
Rat BMSC | Â | Mouse model of MCAO/R | Attenuating neuronal cell damage and promoting angiogenesis in brain endothelial cells | Promoting cell repair and angiogenesis for recovery from brain injury | [108] |
BMSC | miR-29a | C57BL/6J mouse | Promoting angiogenesis and osteogenesis in the body | BMSC-exos can be taken up by human umbilical vein endothelial cells | [109] |
|  | miR-BART1-5p | Mouse model of xenograft tumor | Inhibiting angiogenic mimicry and angiogenesis in nasopharyngeal carcinoma | Regulating VEGF, PI3K, Akt, mTOR and HIF1-α in a Spry2-dependent manner | [113] |
BMSC | miR-133b-3p | KK/Upj-Ay mice | Inhibiting angiogenesis and oxidative stress in diabetic retinopathy | Up-regulating miR-133b-3p or down-regulating FBN1 or BMSC-exos | [114] |
osteosarcoma cell | miR-199a-5p | Human umbilical vein endothelial cells(HUVEC) | Inhibiting the growth and angiogenesis of osteosarcoma | Overexpression of miR-199a-5p | [115] |