Association between adjustable dietary factors and periodontitis: NHANES 2009–2014 and Mendelian randomization

Table 2 MR results for the relationship between diet and periodontitis

Inverse variance weighted	Number of SNPs	Se	OR ^a (95%CI)	P value
Alcohol total consumption	13	0.503	2.768 (1.03e + 00, 7.42e + 00)	0.043
Total dietary sugars	21	0.355	2.123 (1.06e + 00, 4.26e + 00)	0.034
Folic acid and Folate	7	6.549	4.274 (1.14e-05, 1.60e + 06)	0.824
Magnesium	7	3.044	3.443 (8.82e-03, 1.34e + 03)	0.685
Vitamin A	18	4.567	1.855 (2.41e-04, 1.43e + 04)	0.892
Vitamin E	28	0.023	0.994 (9.50e-01, 1.04e + 00)	0.775
Vitamin C	28	0.146	0.984 (7.40e-01, 1.31e + 00)	0.913
Calcium	5	2.058	0.412 (7.30e-03, 2.32e + 01)	0.666
Vitamin D	14	3. 065	0.170 (4.18e-04, 6.92e + 01)	0.563
Zinc	24	3.173	0.143 (2.84e-04, 7.16e + 01)	0.540

^a Indicates the odds for chronic periodontitis per one-s.d. increase in mean of each dietary variable. All statistical tests were two-sided. Results with p value < 0.05 were considered significant and are all bolded. The results of other variables were arranged by OR value size. Abbreviations: SNPs, single-nucleotide polymorphisms; Se, standard error; CI, confidence interval; OR, odds ratio

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