Fig. 4
From: Advancements in lung regeneration: from bench to bedside
General features of MSCs and their function. (A) The conventional phenotype for identification of MSCs contains the expression of CD90, CD73, and CD105, while without expression of HLA-DR, CD14, CD34, and CD45. MSCs can differentiate in vitro into chondrocytes, adipocytes, and osteoblasts when they are isolated once. (B) The biological activities of MSCs in COVID-19 pneumonia (systemic disease) involve antiviral and immunomodulatory function, differentiation of cells, mesenchymal-epithelial transition (MET), and angiogenesis, which is due to therapeutic activity and the paracrine secretion of soluble factors (so-called secretome) [91]