Fig. 4

LRPPRC promotes OXPHOS in TNBC cells. A Quantification of the mRNA of complex I/III, and complex IV/V in SUM-159 cell treated with lentivirus containing control shRNA or LRPPRC-specific shRNA. The components of complex II are all encoded by the nuclear genome and are not shown in the figure. Unpaired t-test was used. B Quantification of the mRNA of complex IV, complex V, complex I, and III in MDA-MB-468 cell treated with lentivirus containing control shRNA or LRPPRC-specific shRNA. Unpaired t-test was used. C Immunoblotting of OXPHOS complex subunits in SUM-159 and MDA-MB-468 cells treated with lentivirus containing control shRNA or LRPPRC-specific shRNA. GAPDH, glyceraldehyde phosphate dehydrogenase. D Correlation analyses of LRPPRC expression and mitochondrial genome-encoded genes in TNBC samples by a public dataset (GSE142102). Simple linear regression test was used