Fig. 1
LRPPRC is upregulated in TNBC tissues and related to a worse prognosis. A LRPPRC mRNA levels were correlated with subtype in the TCGA breast cancer dataset. Student t-test was performed to compare TNBC with other subtypes of breast cancer. B LRPPRC expression levels were correlated with subtype in the CPTAC breast cancer dataset. Student t-test was performed to compare TNBC with other subtypes of breast cancer. C Representative IHC images of non-cancerous tissues (n = 44) and TNBC tissues (n = 84) stained by hematoxylin and eosin (H&E) and with LRPPRC antibody. Staining intensity of LRPPRC in TNBC tissues is classified as negative staining (−), weak staining (+), and strong staining (+ +). The scale bar is 50 pixels. D Percentage of negative staining, weak staining, and strong staining samples in TNBC tissues and non-cancerous tissues with LRPPRC antibody. E, F Kaplan–Meier survival analysis of association of LRPPRC expression with overall survival (OS) and recurrence-free survival (RFS) of patients in the clinical dataset GSE42568. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001