Fig. 4

HEDDI-Net’s applicability and interpretation: Clustering drugs candidates with commonly prescribed drugs in Alzheimer’s disease by affinity. The selected high-confidence drug-like chemicals (rows) were clustered based on the similarity of their binding affinity profiles to the representative proteins (columns). The color bar represents the strength of binding affinity. According to their proximity to two commonly prescribed drugs for Alzheimer's disease, Donepezil and Galantamine, the chemicals were clustered into three groups: the donepezil (colored red), the galantamine (colored green), and others clusters. The proteins selected to display the interpretability of HEDDI-Net were colored to correspond with their respective group. Among the chemicals, drug_1 represents N-(oxo-5,6-dihydrophenanthridin-2-yl)-N, N-dimethylacetamide hydrochloride