Fig. 5

Transcriptome analysis of the role of TET3 in HUCMSC differentiation towards oligodendrocyte progenitor cells (OPCs). a Heatmap showing upregulation of genes promoting oligodendrocyte lineage formation and differentiation and downregulation of inhibitory genes. b Correlation analysis between TET3 expression and multiple genes related to the oligodendrocyte lineage. c–g Positive correlation between TET3 and (c) APC, (d) SOX5, (e) ASH1L, (f) GALC, and (g) IGF1. h–j Negative correlation between TET3 and (h) IL1B, (i) ENG (CD105), and (j) NT5E (CD73). k Suppression of pathways inhibiting oligodendrocyte lineage formation during differentiation. l Negative correlation between TET3 and the Wnt signaling pathway