Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis

Table 3 Association between pre/post changes in VAS and WOMAC and clinical variables within the three arms: Spearman’s rank correlation for pairs of continuous variables, and the coefficient of determination (R²) for associations between a continuous and a categorical variable

Variable	Crest	P	PRP	P	Tibia	P
ΔVAS
Age	−0.14	0.6	0.07	0.8	−0.19	0.5
BMI	0.07	0.8	0.16	0.6	−0.60	0.019
HKA	−0.20	0.5	–	–	0.14	0.6
HCT	−0.26	0.4	–	–	0.03	0.9
%BM	−0.42	0.2	–	–	0.09	0.8
MSCs%	0.26	0.3	–	–	−0.59	0.021
MNC	−0.02	0.9	–	–	−0.02	0.9
Monocytes	−0.06	0.9	–	–	0.55	0.1
PLT	0.12	0.7	–	–	−0.27	0.4
Sex	0.07	0.3	0.07	0.3	0.05	0.4
Side	0.19	0.076	0.07	0.3	0.37	0.008
K-L (I + II) vs (III + IV)	0.56	< 0.001	0.26	0.004	0.06	0.4
ΔWOMAC
Age	−0.12	0.7	−0.10	0.7	−0.35	0.2
BMI	−0.06	0.8	−0.15	0.6	−0.41	0.1
HKA	0.12	0.7	–	–	−0.02	0.9
HCT	−0.30	0.3	–	–	0.09	0.8
%BM	−0.62	0.045	–	–	0.25	0.5
MSCs%	0.18	0.5	–	–	−0.22	0.4
MNC	−0.14	0.7	–	–	0.35	0.3
Monocytes	0.10	0.8	–	–	0.75	0.016
PLTs	−0.27	0.4	–	–	−0.21	0.6
Sex	0.08	0.3	0.01	0.7	0.08	0.3
Side	0.00	1	0.09	0.2	0.40	0.005
K-L (I + II) vs (III + IV)	0.19	0.076	0.10	0.1	0.01	0.7

BMI body mass index, HKA Hip-knee-ankle, HCT hematocrit, BM bone marrow, MSCs mesenchymal stem cells, MNCs mono-nucleated cells, PLTs platelets, KL Kellgren Lawrance, VAS Visual Analogue Scale, WOMAC Western Ontario and McMaster Universities Arthritis Index, ADL Activities of Daily Living, Δ pre/post change, P p-value of the test for the significance of the association

ISSN: 1479-5876