Fig. 1
Ziapin2-mediated modulation of membrane capacitance in AMVMs. (a) Evaluation of capacitance changes in vehicle- (Ctrl) or 25 µM Ziapin2-loaded AMVMs in dark and upon photostimulation at 50 mW/mm2 light power density. Ctrl dark: 245.7 ± 20.5 pF, n = 14; Ctrl l.s: 246.9 ± 19.9 pF, n = 14; Ziapin2 dark: 281.7 ± 23.4 pF, n = 9; Ziapin2 l.s: 263.6 ± 23 pF, n = 9. (b) Percentage of variation in capacitance upon light stimulation (Δ% Ctrl: 0.84 ± 0.6, n = 14; Δ% Ziapin2: -7.2 ± 2.4, n = 9). Data are represented as mean ± SEM. Ctrl: N = 6; Ziapin2: N = 4. Statistical comparison in panel b was performed using the paired Student’s t-test (Ziapin2) or the Mann-Whitney test (Ctrl), depending on the normality of the data distribution