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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms

Fig. 8

Clauidin-1 knockdown induced DIS. A. The mRNA and protein expression of claudin-1 following claudin-1 knockdown (100 nM). Claudin-1 mRNA expression: Ctrl vs. siRNA = 1.0 ± 0.1 vs. 0.2 ± 0.0, P < 0.001; claudin-1 protein expression: Ctrl vs. siRNA = 1.0 ± 0.1 vs. 0.4 ± 0.1, P < 0.01. B. The intercellular space shown by H&E staining following claudin-1 knockdown (100 nM). Ctrl vs. siRNA = 0.5 ± 0.5 μm vs. 1.3 ± 0.2 μm, P < 0.05. Abbreviation: Ctrl: control; DIS: dilated intercellular space; *: P < 0.05; **: P < 0.01; ***: P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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