Fig. 2

The microbiota composition of patients with GER symptoms. A. Microbial composition analysis. B. Unsupervised clustering of esophageal microbiota. C. Analysis of relative abundance of microbiota among different groups. Proteobacteria: G vs. F vs. H vs. D = 38.1% vs. 56.1% vs. 11.7% vs. 16.6%, P < 0.001; Pseudomonas: G vs. F vs. H vs. D = 25.5% vs. 41.9% vs. 0.2% vs. 1.2%, P < 0.05. Abbreviation: G: gastroesophageal reflux disease; F: functional esophageal disorders; D: duodenal ulcer; H: healthy volunteers; *: P < 0.05; **: P < 0.01; ***: P < 0.0001