Fig. 4

Altered expression of transcriptome in early HT. A volcano plot depicted the DEmiRNAs and DEmRNAs in early HT patients and healthy subjects, where blue dots represented down-regulated DEmiRNAs/DEmRNAs in early HT and red dots represented up-regulated ones (|log2FC|> 1, p < 0.05). A clustered heatmap displayed all up-regulated or down-regulated DEmiRNAs, with red modules indicating high enrichment and blue modules indicating low enrichment (A). The functional prediction of DEmRNAs was conducted using KEGG and GO analysis, presenting all differential KEGG pathways and the top 10 GO pathways (BP, CC, and MF), ranked by p-value magnitude (p < 0.05) (B)