Fig. 4
From: PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A
PXD101 inhibits radioresistance of GBM cells through GADD45A. T98G cells and LN229 cells were treated with PXD101 (5µM, 1µM) and transfected with GADD45A siRNA. (A) The survival fractions of T98G cells and LN229 cells were detected using radiosensitivity analysis after 12 h of different IR doses (0 Gy, 2 Gy, 4 Gy, 6 Gy, 8 Gy) treatment. (B) Comet assay was used to analyze the DNA damage. (C) The protein expression of γ-H2AX was analyzed using Western blot. Data are shown as the mean ± SD of three independent experiments. NC: negative control. ***P < 0.001