Fig. 6

shows demonstrates the ability of hBD-1 to mitigate the impact of HAS-CIRCpedia-5280 overexpression in colon cancer cells via miR-4712-5p mimics. (A): The qRT-PCR detected has-circpedia-5280 and miR-4712-5p expression. (B): CCK-8 cell proliferation curve. (C): The cell migration ability was using the scratch assay. (D): MDC staining for intracellular autophagic vesicles. (E): Western blotting for detecting the AKT/mTOR signaling pathway related proteins, LC3II/I ratio, and Beclin-1 expression, the representative Western blotting bands, and the quantification of protein expression. Versus. oe-circRNA+mimic NC, *p<0.05, **p<0.01. Versus. oe-circRNA+mimic NC+hBD-1, #p<0.05, ##p<0.01. Versus. oecircRNA+miR-4712-5p mimic, $p<0.05, $$p<0.01