Fig. 2

The expression level of HAS-CIRCpedia-5280 was significantly down-regulated in colon cancer cells after the action of hBD-1. (A): Volcano plot of differentially expressed circRNAs. (B): Cluster analysis of differentially expressed circRNAs. (C): The KEGG pathway enrichment analysis. D): Detecti on of circRNAs expression vis qRT-PCR. (E-G): The RNaseR resistance test and PCR amplification validated the circular structure of has-circpedia-5280 with polymeric and divergent primers. Versus control group. hBD-1: Human beta-defensin-1, *p<0.05, **p<0.01