Table 2 Applications of mitochondrial transfer in various systemic diseases
From: From dysfunction to healing: advances in mitochondrial therapy for Osteoarthritis
Donor cells | Receptor cells | Result | References |
|---|---|---|---|
Human bone marrow-derived mesenchymal stem cells | Cells with mtDNA mutations that prevent aerobic respiration (A549 ρ° cells) | Mitochondria are transferred to injured cells and their aerobic respiration is restored | [102] |
Human adipose-derived mesenchymal stem cells | Cardiomyocytes | Reprogramming of dividing cardiomyocytes into a viable progenitor-like state via stem cell mitochondrial transfer | [103] |
Rat bone marrow-derived mesenchymal stem cells | Rat cardiomyocytes (H9c2 cells) simulating ischemia/reperfusion injury | Mitochondria are transferred to damaged cells through tunnelling nanotubes, enhancing their anti-apoptotic ability | [104] |
Human bone marrow-derived mesenchymal stem cells | Injured human umbilical cord vein endothelial cells | Mitochondria are transferred to damaged cells through tunnelling nanotubes, reducing apoptosis and restoring transmembrane migration ability | [105] |
Rat bone marrow-derived mesenchymal stem cells | Host cells of cerebral microvasculature in rat stroke model | Significantly improves mitochondrial activity in injured microvasculature through mitochondrial transfer, enhances angiogenesis, reduces the infarct volume, and improves functional recovery | [106] |
Mouse bone marrow-derived mesenchymal stem cells | Odontoblast cell line | Mitochondrial transfer relieves pulp damage | [107] |