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Table 2 Clinical parameters of the “long-term” (more than 3 years) kidney transplant patients

From: Towards clinical translation of urinary vitronectin for non-invasive detection and monitoring of renal fibrosis in kidney transplant patients

> 3 years Tx patients (n = 36)

Fibrosis 0%

(n = 8)

Fibrosis ≥ 5% (n = 28)

p-value

sig

Age (mean ± SD)

58.63

±

12.41

56.36

±

13.86

0.8009 M

ns

Sex (n (male), %)

5

 

63%

17

 

61%

> 0.9999 M

ns

DM (n, %)

3

 

38%

11

 

39%

> 0.9999 M

ns

CVD (n, %)

3

 

38%

10

 

36%

> 0.9999 M

ns

HTA (n, %)

8

 

100%

28

 

100%

> 0.9999 M

ns

BMI (mean ± SD)

28.7

±

4.477

24.95

±

6.794

0.0575 M

ns

ACEi/ARBs

2

 

25%

18

 

64%

0.1034 M

ns

Immunosuppression

        

PDN + CsA (n, %)

0

 

0%

1

 

4%

> 0.9999 M

ns

PDN + CsA + MPS (n, %)

0

 

0%

1

 

4%

> 0.9999 M

ns

PDN + TAC (n, %)

1

 

13%

0

 

0%

0.2222 M

ns

PDN + TAC + MPS (n, %)

6

 

75%

24

 

86%

0.5963 M

ns

PDN + TAC + EVE (n, %)

1

 

13%

2

 

7%

> 0.9999 M

ns

S.Creat (mean ± SD)

2.368

±

0.6803

2.277

±

0.7484

0.7865 M

ns

eGFR (mean ± SD)

27.75

±

9.067

32.79

±

17.18

0.5941 M

ns

Proteinuria (mean ± SD)

534.6

±

683.6

1562

±

1901

0.0363 M

*

Albuminuria (mean ± SD)

190.5

±

339.6

929.3

±

1262

0.0132 M

*

VTN (mean ± SD)

14.71

±

17.81

56.79

±

42.80

0.0040 M

**

VTN/U.Creat (mean ± SD)

0.18

±

0.23

0.99

±

0.80

0.0037 M

**

Years from Tx (mean ± SD)

5.25

±

2.053

6.679

±

2.803

0.1789 M

ns

  1. MMann-Whitney test
  2. DM, diabetes mellitus; CVD, cardiovascular disease; HTA, hypertension; BMI, body mass index; ACEi/ARBs, angiotensin-converting enzyme inhibitor / angiotensin receptor blocker; PDN, prednisone; CsA, cyclosporine A; MPS, mycophenolate sodium; TAC, tacrolimus; EVE, everolimus; S.Creat, serum creatinine; eGFR, estimated glomerular filtration rate; VTN, Vitronectin; U.Creat, urinary creatinine; Sig, significance; ns, non-significant (p-value > 0,05); *p-value < 0.05 and **p-value < 0.01