Fig. 1

Analysis of all KTx patients. (A) Spearman’s correlation coefficient matrix. Spearman r values are indicated in bold and p-values of the correlation are indicated at the bottom if p-value < 0.2. P-values > 0.2 are indicated as ns. (B) Violin plots showing the descriptive statistics and statistical differences according to the parameter “years from transplantation”, (C) albuminuria levels, (D) VTN levels obtained by ELISA and (E) VTN levels normalized by urinary creatinine, stratified regarding the percentage of fibrosis observed in the kidney biopsies. Statistical differences are indicated for *p < 0.05 and **p < 0.01 by a Mann-Whitney test. (F) ROC curve based on “years from transplantation”, (G) albuminuria (H) VTN, and (I) VTN normalized by urinary creatinine, as a unique biomarker to differentiate the two groups of patients (no fibrosis vs. fibrosis). VTN, Vitronectin; U.Creat, urinary creatinine; mALB, albuminuria