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Table 1 Clinical and pathological characteristics of the study population

From: The intra-tumoral microbiome as a potential biomarker of response to external beam radiation therapy in cervical cancer

Characteristics

Whole sample (n = 36)

IR group

(n = 10)

SR group

(n = 26)

p

Age at diagnosis (years, IQR) a

55.50 (49.00-66.75)

51.50 (50.00-68.25)

56.50 (45.00-66.75)

0.764c

Age at diagnosis, n (%) b

   

1.000d

 ≤ 50years

14 (38.9)

4 (28.6)

10 (71.4)

 

 > 50years

22 (61.1)

6 (27.3)

16 (72.7)

 

FIGO stage (2018), n (%) b

   

1.000d

 IA-IIA

2 (5.6)

0 (0.0)

2 (100.0)

 

 IIB-IVB

34 (94.4)

10 (29.4)

24 (70.6)

 

Histological type, n (%) b

   

0.370d

 Squamous cell carcinoma

29 (80.6)

7 (24.1)

22 (75.9)

 

 Adenocarcinoma

7 (19.4)

3 (42.9)

4 (57.1)

 

Histological differentiation, n (%) b

   

0.608d

 G1 well-differentiated

3 (8.3)

1 (33.3)

2 (66.7)

 

 G2 moderately-differentiated

15 (41.7)

6 (40.0)

9 (60.0)

 

 G3 poorly- differentiated

3 (8.3)

0 (0.0)

3 (100.0)

 

 Unknown

15 (41.7)

3 (20.0)

12 (80.0)

 

Maximal tumor size (cm, IQR) a

5.35 (4.03–6.98)

5.55 (4.63–7.48)

5.30 (3.98–6.90)

0.243c

Maximal tumor size (cm), n (%) b

   

0.155d

 ≤ 4

7 (19.4)

0 (0.0)

7 (100.0)

 

 > 4

29 (80.6)

10 (34.5)

19 (65.5)

 

Lymph nodes metastases, n (%) b

   

0.463d

 Yes

17 (47.2)

6 (35.3)

11 (64.7)

 

 No

19 (52.8)

4 (21.1)

15 (78.9)

 

HPV status, n (%) b

   

0.597d

 Positive

18 (50.0)

4 (22.2)

14 (77.8)

 

 Negative

2 (5.6)

1 (50.0)

1 (50.0)

 

 Unknown

16 (44.4)

5 (31.3)

11 (68.7)

 

BMI b

   

0.549d

 ≤ 18.5

2 (5.6)

0 (0.0)

2 (100.0)

 

 18.5 < BMI ≤ 25

20 (55.6)

5 (25.0)

15 (75.0)

 

 25 < BMI ≤ 30

12 (33.3)

5 (41.7)

7 (58.3)

 

 > 30

2 (5.6)

0 (0.0)

2 (100.0)

 

Menstrual status b

   

0.438d

 Pre- menopausal status

12 (33.3)

2 (16.7)

10 (83.3)

 

 Post-menopausal status

24 (66.7)

8 (33.3)

16 (66.7)

 

Hypertension history b

   

1.000d

 No

25 (69.4)

7 (28.0)

18 (72.0)

 

 Yes

11 (30.6)

3 (27.3)

8 (72.7)

 

Diabetes history b

   

0.181d

 No

33 (91.7)

8 (24.2)

25 (75.8)

 

 Yes

3 (8.3)

2 (66.7)

1 (33.3)

 

Marital status b

   

0.545d

 Married

33 (91.7)

10 (30.3)

23 (69.7)

 

 Divorced

3 (8.3)

0 (0.0)

3 (100.0)

 

Socioeconomic status b

   

0.708d

 Lower

9 (25.0)

2 (22.2)

7 (77.8)

 

 Middle

17 (47.2)

6 (35.3)

11 (64.7)

 

 Upper

10 (27.8)

2 (20.0)

8 (80.0)

 

EBRT treatment modality b

   

0.686d

 With CCT

27(75.0)

7(25.9)

20(74.1)

 

 Without CCT

9(25.0)

3(33.3)

6(66.7)

 
  1. Abbreviations: IQR, interquartile range; FIGO, International Federation of Gynecology and Obstetrics; SR, superior response; IR, inferior response; HPV, human papilloma virus infection; BMI, body mass index; EBRT, external beam radiation therapy; CCT, concurrent chemotherapy.
  2. Data are presented as numbers median (interquartile range) a or (percentages) b.
  3. cp-value was calculated using Wilcoxon rank-sum test.
  4. dp-value was calculated using Fisher’s exact test.