Fig. 11

Risk of bias assessment of the 83 reviewed studies based on SYRCLE’s ROB tool represented by RevMan 5.4. [1] Randomization (selection bias); [2] Random sequence generation (selection bias); [3] Baseline characteristics (selection bias); [4] Allocation concealment; [5] Random housing (performance bias); [6] Blinding of personnel (performance bias); [7] Blinding of outcome assessment (detection bias); [8] Incomplete outcome data (attrition bias); [9] Selective reporting (reporting bias); [10] other sources of bias (attrition bias). A domain concerning the declaration of the randomization method was added (domain 1), while the domain of “blinding of outcome assessment” was not covered in this review