Fig. 6

Comparison of gene expression in sPitNETs with a high level of aneuploidy (multiple chromosomal duplications) and cytogenetically stable tumors. A) Results of the dimensionality reduction analysis results; B) Whole transcriptome-based clustering and the expression of top the most variably expressed genes; C) Differentially expressed genes plotted according to chromosomal location. Each dot represents a particular gene. D) Top 10 most enriched upregulated and downregulated GO biological processes; E) All significantly enriched GO biological processes classified according to a common physiological role; F) Comparison of the expression of mitotic spindle-, chromosome segregation-, DNA damage response-related genes that were identified as downregulated in tumors with high aneuploidy (multiple chromosomal duplications). *- indicates p = 0.01 to 0.05, **- indicates p = 0.001 to 0.01, ***- indicates p = 0.0001 to 0.001, ****- indicates p > 0.0001