Fig. 5

Comparison of gene expression between sPitNETs with chromosome 11 deletion and cytogenetically stable ones. A) Results of the dimensionality reduction analysis; B) Clustering and the expression of the most variably expressed genes; C) Differentially expressed genes plotted according to chromosomal location. Each dot represents a particular gene. D) Top 10 most enriched upregulated and downregulated GO biological processes; E) All significantly enriched GO biological processes classified according to a common physiological role; F) Comparison of the expression of known cancer-related genes encoded on chromosome 11 identified as differentially expressed. **- indicate p = 0.001 to 0.01, ***- indicate p = 0.0001 to 0.001