Fig. 4

Relationship between CNAs and genes expression or DNA methylation profiles. A) Genes expression in tumor samples clustered according to cytogenetic pattern (reflecting Fig. 1B). The heat map shows the mean expression of genes encoded by each chromosome band. The boxes indicate sites of chromosomal loss. The dendrogram shows similarity in the pattern of CNAs; B) Correlation between the expression and copy number value of each gene, Spearman R > |0.5| was used as a cut-off point for moderate/high correlation. Each dot represents a particular gene; C) Correlation between CNAs count and median DNA methylation (median β-value) at specified category of CpG sites; D) Normalized, scaled DNA methylation level in individual sPitNETs showing difference in DNA methylation at CpG island and genes promoters at deleted chromosomal regions from the methylation level from the other chromosomal regions. Boxes indicate sites of chromosomal loss. The dendrograms show similarity in pattern of CNAs; E) Correlation between expression and copy number value of each gene, Pearson R > |0.5| was used as a cut-off point for moderate/high correlation. Each dot represents a chromosomal band