Fig. 1

Genome-wide DNA copy number profile in somatotroph pituitary tumors. A) Representative examples of virtual karyotypes with copy number patterns observed in the study, based on low pass WGS coverage (WGS RD line), SNP biallelic frequency (CystoSNP BAF line), and microarray probe signal (CystoSNP LRR line); B) Landscape of copy number alteration (CNAs) in sPitNETs with a resolution of single chromosomal bands. The dendrograms based on similarity in the CNAs pattern indicate two main cytogenetic clusters of the tumors; C) Comparison of the number of chromosomal deletions and duplications in two major cytogenetic clusters of tumors. D) Correlation between frequency of incidence of the duplications and deletions at particular chromosomal regions (bands) and gene density; E) CNA signatures for each of the three somatotroph tumor clusters and their comparison to known CNA signatures found in human cancers [30] by measuring Euclidiean similarity; F) The comparison of CNAs profile in sPitNEts and human cancers included in TCGA project