Fig. 3

Transcription factor enrichment analysis. (A) Barplot of enriched binding motifs (y-axis), ordered based on -log10 p-value (x-axis), encoded by the hyperDMRs (B) Volcano plot shows the differentially active TFs estimated comparing 41 BRCA + tumor samples versus 41 solid tissue normal tissue samples of the TCGA-BRCA cohort. The positively dysregulated TFs are shown in red while the negatively dysregulated TFs are shown in green. The TFs with an absolute value of delta greater or equal to 1 and False Discovery Rate (FDR) < 0.05 were selected as dysregulated. The dysregulated TFs identified with VIPER and HOMER were labeled in the volcano plot