Fig. 6

TGFb signaling in self-communication of S100P + TFF1 + tumor cells. A Role of spread through air spaces (STAS) tumor subclusters in cell–cell communication. B Outgoing signaling pattern of all cell clusters. C Incoming signaling pattern of all cell clusters. D Ligand-receptor pairs in TGFb signaling pathway signaled from T4/T5 to other clusters. E TGFb signaling pathway network. F MIF image revealing the TGFB2-TGFBR2 ligand-receptor pair in the self-cell–cell communication of S100P + TFF1 + tumor cells