Fig. 5

S100P + TFF1 + tumor cells correlated with worse EGFR-TKI therapy and immunotherapy response. A Distribution of cells in non-responders (NR) and responders (R) receiving EGFR-TKI therapy. B Distribution of S100P and TFF1 in NR and R receiving EGFR-TKI therapy. C S100P and TFF1 measured by enzyme-linked immunosorbent assay (ELISA) kit showed the most significant upregulation in NR compared to R. D TFF1 showed a significant adverse association with worse clinical outcomes in EGFR-TKI-treated patients. E Distribution of S100P and TFF1 in NR and R receiving immunotherapy. F Role of S100P and TFF1 in predicting the therapeutic results of immunotherapy