Fig. 3

S100P + TFF1 + tumor cells in spread through air spaces (STAS) sample correlated with worse prognosis in non-small cell lung cancer (NSCLC). A The expression profiles of classical cell types marker genes for copy number variation (CNV) clusters. B The expression profiles of the top 5 marker genes for each cluster. C The distinct pathway activities among these clusters. D The top3 up-regulated and down-regulated transcription factors among these clusters. E The signature of T4 and T5 showed adverse role in patients’ survival time. F Distribution of S100P and TFF1 in CNV clusters. G The spatial distribution of TFF1 in STAS sample. H The single-cell dataset was divided into five main clusters: epithelial cells, myeloid cells, fibroblasts, endothelial cells, and T/B cells. I Expression patterns of S100P and TFF1 in single-cell level