Fig. 2

Circulating levels of anti- and pro-inflammatory cytokines in GluR3B antibody-positive and antibody-negative epilepsy patients. Representation of the mean fold change and corresponding P values in parameters between GluR3B antibody positive (n = 36) and GluR3B antibody negative (n = 28) peripheral blood in drug-resistant epilepsy (A). The circulating levels of IL-1β, IL-8 and IFN-γ are shown in antibody-positive and antibody-negative drug-resistant patients (B-D). Representation of the mean fold change and corresponding P values in parameters between GluR3B antibody positive (n = 8) and GluR3B antibody negative (n = 33) peripheral blood in drug-responsive epilepsy (E). The circulating levels of IL-1β and IFN-γ are shown in antibody-positive and antibody-negative drug-responsive patients (F-G). Representation of the mean fold change and corresponding P values in parameters between GluR3B antibody positive (n = 9) and GluR3B antibody negative (n = 57) peripheral blood in drug-naïve epilepsy (H). The circulating levels of IL-1β are shown in antibody-positive and antibody-negative drug-naïve patients (I). Correlation (Spearman) of the serum concentration of GluR3B antibody with circulating levels of multiple cytokines (IL-1β, IL-8, and IFN-γ) (J-L). Statistical analysis was performed by Mann-Whitney U test