Fig. 9
From: Berberine-loaded PLGA nanoparticles alleviate ulcerative colitis by targeting IL-6/IL-6R axis
Targeting of IL-6/IL-6R axis by BPL-NPs and the associated downstream signals. A: IF staining of IL-6R in NCM-460 cells; B: Protein expression of IL-6 and IL-6R; C: Total protein expression and phosphorylation level of JAK1, STAT3, p-JAK1, and p-STAT3; D: Relative mRNA expression of NF-κB; E: Protein expression of NF-κB; F: IF staining of Caspase-3 in NCM-460 cells. **P < 0.01