Fig. 4

Genomic responses of the heart following doxorubicin treatment. Panel A: Differentially expressed genes and enriched biological processes after doxorubicin treatment. (A1) Venn diagram of common and doxorubicin treatment specific (T1-T4) DEGs in the heart. (A2) Heatmap of differentially expressed genes. The heatmap was generated with an average-linkage Euclidean distance hierarchical clustering algorithm, and depicted is the fold change for DEGs. (A3) Heatmap of significantly enriched biological processes (p-value < 0.01) for treatment specific DEGs. Gene ontologies are Metascape web-tool based. Panel B: Commonly regulated genes in cardiac tissue among the different treatment groups. Panel C: Magnitude of gene expression changes and their frequency in the different treatment groups