Fig. 2
From: miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK
Effects of miR-876 overexpression on melanoma colony formation and cell cycle progression. A, B Relative expression by qRT-PCR of miR-876 (panel A) in C8161.9 and A375 (panel B) stable transformants. C, D Bar graphs showing the average number of colonies in C8161.9 (panel C) and A375 (panel D) cells stably expressing miR-876 compared to a control-miR (termed cont. miR) sequence, along with representative bright field images of C8161.9 and A375 colonies in culture stably expressing miR-876 vs control-miR. Data are shown as the mean ± SEM. *P < 0.05 denotes statistically significant differences compared with control. E, F Cell cycle profile with accompanied analysis of distribution of C8161.9 (panel E) and A375 melanoma (panel F) cells stably expressing either miR-876 or control-miR in different phases of the cell cycle