Fig. 5

Correlation between ICEP2 CD8 + T cell infiltration and LGMN⁺ macrophage infiltration. A Analysis of correlation between CD8⁺ T cell subpopulations and infiltration of other cell types in the TME in the TCGA-STAD cohort (Pearson correlation coefficient Rs > 0.3 and P-value < 0.05 considered significant, Pie chart showing correlations with a P-value < 0.05). B UMAP plot annotating myeloid cell subsets in gastric cancer patients. C Heatmap displaying the distribution of myeloid cell subpopulations based on the ratio of observed cell counts to expected cell counts (Ro/e) calculated using a chi-square test. The top bar plot shows cell composition, and the right bar plot shows the total number of cells in each subsets. D Violin plot illustrating the functional characteristic scores of monocyte-macrophage subsets. E Analysis of correlation between CD8⁺ T cell subsets and infiltration of other cell types in the TME in the TCGA-STAD cohort. F Kaplan–Meier curve demonstrating the relationship between LGMN⁺ macrophage infiltration and overall survival (OS) of TCGA-STAD patients