Fig. 5

T cell microenvironment is actively mobilized in the high-risk MDS. A Somatic mutation calling was conducted by SComatic computing. See Methods for details. B No significant difference of mutation burden was found in the three groups. C Circular plots showing the overall differential cell–cell communications strength between high-risk MDS group and healthy controls or between low-risk MDS group and healthy controls. Red lines indicate an increased interaction while blue lines indicate a decreased interaction. D–F Scoring T cell activity based the gene sets related to T cell inflammation, T cell exhaustion, T cell cytotoxicity and T cell immune surveillance. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001