Fig. 3

Aberrant and deficient hematopoiesis visualized by simulating the developmental time of each cell. A A schematic illustrating the developmental trajectory from HSPCs to neutrophils and monocytes. B Violin plot of the indicated cell types. The pseudotime value of each cell is simulated by the algorithm Palantir. C Expression of indicated genes along the pseudotime axis. The function of each gene is also labeled according to the experimental results. D The high-risk MDS group manifests overactivated interferon alpha and gamma signaling along with increased inflammation response while the low-risk MDS group does not. ***, p < 0.001