Fig. 5
From: Hydrogel-based platforms for site-specific doxorubicin release in cancer therapy
Reprinted with permission from Elsevier [165]
The development of thermos- and light-responsive hydrogels for delivery of DOX and gemcitabine. Left side) A schematic representation for the design of thermo- and light-sensitive hydrogels in the co-delivery of doxorubicin and gemcitabine. Right side) (a) The presence of UV-triggered gel-to-sol transition and release of cargo in response to temperature. (b, c) The release profile of gemcitabine (b) and doxorubicin (c) from the hydrogels. (e, f) Cumulative release of gemcitabine and doxorubicin. (d) Release profile of cargo in presence or lack of 10Â min UV irradiation. (g) The cumulative release in response to temperature for doxorubicin and gemcitabine within the first 10Â h from the non-treated and UV-irradiated (10Â min) hydrogels.