Table 2 Summary of DC-derived-EV molecules and their functions
DC-derived EV content | Function | Refs |
|---|---|---|
Annexin II; Gi2a | Exosome function and biogenesis | 88–92; 103 |
MFG-E8; MAC1; CD9 | Association to target cells | 88–92; 103 |
MHCI; MHCII; CD86 | T cell activation | 88–92; 103 |
MFG-E8 | Binds to integrins expressed in dendritic cells and macrophages | 102–103 |
Hsp70 | Antitumor effects through citotoxic T lymphocytes | 91–97 |
Hsc73 | Antitumor effects Exosome function or biogenesis | 91–97 |
ICAM1 | Induce stronger T cell response | 96–97 |
TNFa; FasL; TRAIL | Induce caspase activation and apoptosis in tumor cells Activate NK and IFNg production | 109 |
miRNA | Silencing of transcrits encoding immune-stimulatory molecules Repress target mRNAs of acceptor DCs | 98–100 |
NK ligand (BAT3; NKG2D) | Induce NK innate function Induce cytokine production Induce NK cell activation and proliferation | 105–109 |