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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Extracellular vesicles at the crossroad between cancer progression and immunotherapy: focus on dendritic cells

Fig. 3

Mechanisms of T cell stimulation by DC-derived extracellular vesicles. DC-derived EVs can present antigens via MHC molecules and stimulate T cell responses either directly or indirectly. Direct T cell stimulation is mediated by peptide/MHC complexes presented on the surface of DC-derived EVs. Indirect T cell stimulation mechanisms include the transfer of antigenic peptide/MHC to bystander DCs or by “cross-dressing”, in which EVs merge to the membrane of the acceptor DCs or cancer cells

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Journal of Translational Medicine

ISSN: 1479-5876

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