Fig. 2

Composition and functions of tumor- and dendritic cell-derived extracellular vesicles. (A)Tumor-derived EVs have been shown two contradictory functional interactions with dendritic cells (DCs): stimulation (depicted on the left) and inhibition of tumor antigen presentation (right side). (B) DC-derived EVs express anti-apoptotic molecules, RNA species that favor innate immune cell activation, molecules involved in antigen presentation and adhesion-associated proteins that enhance EV uptake. Numbers in brackets refer to relevant literature references