Fig. 1

Inhibiting FOXM1 and BCL2 prolongs the survival of NSG mice engrafted with OPM2 cells. (A) The experiment involved transplanting OPM2 cells expressing Renilla Luciferase into NSG mice via tail vein. Successful engraftment was confirmed using IVIS imaging at the third week. Mice were then divided into four groups based on similar Luciferase activities and treated with NB73, Venetoclax, or their combination as indicated. (B) Survival curves show that inhibiting FOXM1 and BCL2 prolonged the survival of NSG mice engrafted with OPM2 cells compared to controls. Statistical analysis using Logrank test with Bonferroni correction for multiple comparisons was performed to calculate p values