Fig. 6

Chemometric analysis of metabolites and identification of key metabolites A and C OPLS-DA score plots for Group B vs. A (A) and Group C vs. B (C). B and D Cross-validation results of OPLS-DA model for Group B vs. A (B) and Group C vs. B (D). E and F OPLS-DA S-plot of LC-MS data for Group A&B samples (E) and Group B&C samples (F), respectively. G Overlapping and shared metabolites between Group B vs. A and Group C vs. B suggested by the Venn plot. H Heatmap displaying expression patterns of 11 key metabolites across three groups