Fig. 2

Impact of CBLB overexpression on body weight and cardiac morphology in mice with AMI. A Post-surgical body weight fluctuations across 0–14 days in the Sham, AMI, and AMI + CBLB overexpression mice groups, demonstrating a trend towards weight loss, particularly significant in the AMI group. B Comparative analysis of the cardiac hypertrophy index level among the three mice groups, revealing that AMI group has a significantly larger index compared to the Sham group, suggesting the impact of acute myocardial infarction on myocardial hypertrophy, with no significant difference observed between AMI and AMI + CBLB groups. C Photographic documentation of the overall heart morphology in the three mice groups, showing visible infarcted tissue in the left ventricular wall of AMI and AMI + CBLB groups. D Representative images of TTC staining of infarcted areas of the myocardium (infarcted area is in white), illustrating a deeper penetration of the infarcted area into the inner layer of the left ventricular wall in AMI and AMI + CBLB groups, with some reduction in the infarcted area observed in the AMI + CBLB group. These observations signify the potential protective role of CBLB in AMI. All the data are expressed as mean ± SEM; n = 6 per group. * P < 0.05, ns, no statistical significance