Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations

Keller, Betsy; Receno, Candace N.; Franconi, Carl J.; Harenberg, Sebastian; Stevens, Jared; Mao, Xiangling; Stevens, Staci R.; Moore, Geoff; Levine, Susan; Chia, John; Shungu, Dikoma; Hanson, Maureen R.

doi:10.1186/s12967-024-05410-5

Table 6 Intraclass correlation coefficients (ICC) between CPET-1 and CPET-2 at ventilatory/anaerobic threshold (VAT) for ME/CFS and Controls

From: Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations

Variable at VAT	Total sample				VO₂peak-matched pairs
	ME/CFS (n = 84)		Controls (n = 71)		ME/CFS (n = 55)		Controls (n = 55)
	ICC	95% CI	ICC	95% CI	ICC	95% CI	ICC	95% CI
Work (W)	0.64^*	.49–.75	0.76^**	.64–.84	0.50^*	.27–.67	0.81^**	.69–.88
Time to level (sec)	0.62^*	.47–.73	0.76^**	.65–.85	0.48	.25–.66	0.82^**	.70–.89
RER	0.67^*	.53–.77	0.46	.26–.63	0.62^*	.43–.76	0.45	.21–.64
\(\dot{\text{V}}\)e (L/min)	0.65^*	.51–.76	0.83^**	.75–.89	0.65^*	.47–.78	0.87^**	.78–.92
RR (breaths/min)	0.58^*	.42–.71	0.58^*	.40–.71	0.59^*	.39–.74	0.59^*	.39–.74
\(\dot{\text{V}}\)_T (L/min)	0.70^*	.58–.80	0.80^**	.70–.87	0.72^*	.56–.82	0.79^**	.67–.87
\(\dot{\text{V}}\)O₂ (ml^.kg^−1.min⁻¹)	0.72^*	.58–.81	0.90^***	.84–.93	0.68^*	.49–.80	0.92^***	.85–.95
\(\dot{\text{V}}\)O₂ (ml/min)	0.76^**	.66–.85	0.92^***	.87–.95	0.77^**	.62–.86	0.92^***	.87–.95
\(\dot{\text{V}}\)CO₂ (ml/min)	0.69^*	.55–.79	0.84^**	.76–.90	0.64^*	.45–.77	0.85^**	.75–.91
\(\dot{\text{V}}\) e/\(\dot{\text{V}}\)O₂	0.68^*	.55–.78	0.60^*	.43–.73	0.70^*	.53–.81	0.63^*	.44–.77
\(\dot{\text{V}}\)e/\(\dot{\text{V}}\)CO₂	0.73^*	.52–.84	0.75^**	.63–.84	0.71^*	.48–.84	0.80^**	.63–.89
HR (bpm)	0.60^*	.45–.72	0.67^*	.52–.78	0.60^*	.40–.75	0.69^*	.52–.81
O₂pulse (\(\dot{\text{V}}\)O₂/HR)	0.90^**	.86–.92	0.93^***	.89–.96	0.89^***	.79–.94	0.95^***	.91–.97
SBP (mmHg)	0.80^**	.69–.87	0.68^*	.53–.79	0.82^**	.70–.89	0.67^*	.50–.79
DBP (mmHg)	0.76^**	.63–.84	0.80^**	.70–.87	0.74^*	.59–.84	0.82^**	.67–.89
PP (mmHg)	0.72^*	.59–.81	0.55^*	.36–.69	0.64^*	.46–.77	0.52^*	.30–.69
RPP	0.68^*	.54–.78	0.56^*	.37–.70	0.64^*	.46–.77	0.58^*	.38–.73
PETO₂ (mmHg)	0.68^*	.55–.78	0.66^*	.51–.78	0.72^*	.56–.82	0.66^*	.48–.78
PETCO₂ (mmHg)	0.76^**	.57–.86	0.80^**	.70–.87	0.75^**	.49–.87	0.82^**	.63–.90
RPE (6–20)	0.64^*	.50–.75	0.65^*	.50–.77	0.66^*	.49–.79	0.71^*	.55–.82

Time to level = time to peak exertion; RER respiratory exchange ratio, \(\dot{\text{V}}\)e minute ventilation, RR respiratory rate, \(\dot{\text{V}}\) _T tidal volume, \(\dot{\text{V}}\)e/\(\dot{\text{V}}\)O₂ ventilatory equivalent of oxygen, \(\dot{\text{V}}\)e/\(\dot{\text{V}}\)CO₂ ratio of ventilatory equivalent of carbon dioxide, HR heart rate; SBP systolic pressure, DBP diastolic pressure, PP pulse pressure, RPP rate pressure product, PETO₂ pressure end tidal O₂, PETCO₂ pressure end tidal CO₂, RPE rating of perceived exertion (6–20); *moderate reliability, **good reliability, ***excellent reliability.

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