Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations

Keller, Betsy; Receno, Candace N.; Franconi, Carl J.; Harenberg, Sebastian; Stevens, Jared; Mao, Xiangling; Stevens, Staci R.; Moore, Geoff; Levine, Susan; Chia, John; Shungu, Dikoma; Hanson, Maureen R.

doi:10.1186/s12967-024-05410-5

Table 5 Intraclass correlation coefficients (ICC) between CPET-1 and CPET-2 at peak VO₂ for ME/CFS and Controls

From: Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations

	Total sample				VO₂peak-matched pairs
	ME/CFS (n = 84)		Controls (n = 71)		ME/CFS (n = 55)		Controls (n = 55)
Variable at Peak	ICC	95% CI	ICC	95% CI	ICC	95% IC	ICC	95% CI
Work (W)	0.87^**	.78–.92	0.95^***	.92–.97	0.80^**	.67–.87	0.95^***	.92–.97
Time to level (sec)	0.83^**	.72–.89	0.87^**	.80–.92	0.73^*	.56–.83	0.86^**	.78–.92
RER	0.65^*	.50–.76	0.60^*	.42–.73	0.63^*	.50–.73	0.65^*	.47–.78
\(\dot{\text{V}}\)e (L/min)	0.82^**	.70–.89	0.87^**	.80–.92	0.81^**	.67–.88	0.88^**	.81–.93
RR (breaths/min)	0.74^*	.63–.82	0.76^**	.65–.85	0.74^*	.65–.82	0.78^**	.65–.86
\(\dot{\text{V}}\)_T (L/min)	0.85^**	.76–.90	0.90^***	.84–.93	0.84^**	.77–.90	0.93^***	.88–.96
\(\dot{\text{V}}\)O₂ (ml^.kg^−1.min⁻¹)	0.86^**	.75–.92	0.88^**	.82–.92	0.82^**	.65–.90	0.91^***	.84–.94
\(\dot{\text{V}}\)O₂ (ml/min)	0.87^**	.77–.92	0.91^***	.85–.94	0.86^**	.69–.92	0.93^***	.88–.96
\(\dot{\text{V}}\)CO₂ (ml/min)	0.84^**	.69–.91	0.88^**	.81–.92	0.78^**	.59–.87	0.90^**	.82–.94
\(\dot{\text{V}}\)e/\(\dot{\text{V}}\)O₂	0.71^*	.58–.80	0.68^*	.53–.79	0.70^*	.59–.78	0.70^*	.54–.82
\(\dot{\text{V}}\)e/\(\dot{\text{V}}\) CO₂	0.74^*	.63–.83	0.79^**	.69–.86	0.77^**	.68–.84	0.79^**	.67–.87
HR (bpm)	0.79^**	.67–.86	0.79^**	.69–.86	0.80^**	.65–.87	0.85^**	.75–.91
O₂pulse (\(\dot{\text{V}}\)O₂/HR)	0.87^**	.81–.92	0.90^***	.85–.94	0.88^***	.81–.93	0.92^***	.87–.95
SBP (mmHg)	0.86^**	.79–.91	0.85^**	.77–.90	0.84^**	.78–.89	0.87^**	.79–.92
DBP (mmHg)	0.71^*	.58–.81	0.73^*	.60–.82	0.73^*	.62–.81	0.79^**	.66–.87
PP (mmHg)	0.76^**	.65–.84	0.78^**	.67–.86	0.72^**	.61–.80	0.79^**	.66–.87
RPP	0.83^**	.74–.89	0.80^**	.70–.87	0.82^**	.71–.89	0.85^**	.75–.91
PETO₂ (mmHg)	0.75^**	.64–.83	0.70^*	.55–.80	0.77^**	.68–.84	0.67^*	.49–.79
PETCO₂ (mmHg)	0.80^**	.71–.87	0.78^**	.66–.85	0.82^**	.75–.87	0.78^**	.65–.87
RPE (6–20)	0.54^*	.37–.67	0.59^*	.41–72	0.50^*	.35–.63	0.56^*	.35–.72

Time to level = time to peak exertion, RER respiratory exchange ratio, \(\dot{\text{V}}\)e minute ventilation, RR respiratory rate, \(\dot{\text{V}}\)_T tidal volume. \(\dot{\text{V}}\)e/\(\dot{\text{V}}\)O₂ ventilatory equivalent of oxygen, \(\dot{\text{V}}\)e/\(\dot{\text{V}}\)CO₂ ratio of ventilatory equivalent of carbon dioxide, HR heart rate, SBP systolic pressure, DBP diastolic pressure, PP pulse pressure, RPP rate pressure product, PETO₂ pressure end tidal O₂, PETCO₂ pressure end tidal CO₂, RPE rating of perceived exertion (6–20)
*moderate reliability, **good reliability, ***excellent reliability

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ISSN: 1479-5876

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