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Table 1 Overview of all pulmonary function parameters measured using the FlexiVent instrument

From: Bicyclol attenuates pulmonary fibrosis with silicosis via both canonical and non-canonical TGF-β1 signaling pathways

Physiological significance

PFTs

Control

SiO2

BIC

Expiratory capacity

FEV0.05/FVC (%)

22.74 ± 1.94***

8.47 ± 0.41

8.66 ± 0.38

FEV0.1/FVC (%)

61.81 ± 2.88***

18.87 ± 0.90

23.10 ± 1.33

FEV0.2/FVC (%)

90.99 ± 1.37***

54.12 ± 1.67

66.15 ± 2.83***

FEF0.05 (mL/s)

77.98 ± 9.863***

22.30 ± 0.4621

23.67 ± 0.6889

FEF0.1 (mL/s)

61.65 ± 11.19**

24.66 ± 0.4975

56.16 ± 8.570*

FEF0.2 (mL/s)

8.616 ± 1.419***

41.29 ± 4.464

36.50 ± 6.275

TPEF (s)

0.04167 ± 0.002991***

0.1915 ± 0.003058

0.1401 ± 0.007048***

Inspiratory capacity

IC (mL)

12.99 ± 0.3719***

8.127 ± 0.2928

9.764 ± 0.2988**

Static compliance

Cst (mL/cmH2O)

1.411 ± 0.06125***

0.5847 ± 0.05721

0.8768 ± 0.04969**

Elastance

Ers (cmH2O/mL)

1.095 ± 0.04837***

2.577 ± 0.3897

1.951 ± 0.1893

Compliance

Crs (cmH2O/mL)

0.9291 ± 0.03941***

0.4447 ± 0.04983

0.5548 ± 0.05581

Resistance

Rrs (cmH2O.s/mL)

0.1350 ± 0.01884

0.1571 ± 0.02701

0.1337 ± 0.01876

Central airway resistance

Rn (cmH2O.s/mL)

0.03439 ± 0.003290***

0.07001 ± 0.006044

0.06728 ± 0.007056

Tissue damping

G (cmH2O/mL)

0.2930 ± 0.02932

0.4328 ± 0.04720

0.5304 ± 0.06135

Tissue elastance

H (cmH2O/mL)

1.071 ± 0.1216***

1.983 ± 0.1492

1.795 ± 0.1361

Tissue hysteresivity

G/H

0.2772 ± 0.008842

0.2360 ± 0.04549

0.3060 ± 0.04131

  1. All data are presented as mean ± SEM (*p < 0.05, **p < 0.01, and ***p < 0.001 compared to the SiO2 group (n = 9 per group))