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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Progression patterns, resistant mechanisms and subsequent therapy for ALK-positive NSCLC in the era of second-generation ALK-TKIs

Fig. 2

Potential mechanism of second-generation ALK-TKI resistance. The NGS results following second-generation ALK-TKI resistance in 44 patients were subjected to statistical analysis, revealing that secondary mutations in ALK kinase domains (25/44, 56.8%) represent the primary mechanism of resistance. And G1202R mutation was the most common mutation site (12/25, 48.0%) in ALK kinase domains

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Journal of Translational Medicine

ISSN: 1479-5876

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